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Human milk stimulates B cell function.

P Juto

    Archives of Disease in Childhood
    |July 1, 1985
    PubMed
    Summary

    Human milk enhances B cell proliferation and antibody secretion, unlike formula milk. This immune-boosting effect, mediated by heat-sensitive factors in breast milk, contributes to its anti-infectious properties.

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    Area of Science:

    • Immunology
    • Human milk research
    • Cellular immunology

    Background:

    • B cells are crucial for adaptive immunity and antibody production.
    • Human milk possesses known anti-infectious properties.
    • Understanding the immunological components of human milk is vital.

    Purpose of the Study:

    • To investigate the impact of human milk on B cell function.
    • To compare the effects of human milk and formula on B cell activity.
    • To identify potential mechanisms behind breast milk's protective qualities.

    Main Methods:

    • Murine spleen cells were stimulated with suboptimal doses of lipopolysaccharide (LPS).
    • Effects of cell-free, defatted, filtered colostrum and mature breast milk were assessed.
    • B cell proliferation and antibody secretion were measured.
    • Activity was tested for heat sensitivity and dialysis resistance.

    Main Results:

    • Both colostrum and mature breast milk significantly enhanced B cell proliferation and antibody secretion.
    • Formula milk did not exhibit this enhancing effect.
    • The active component in human milk was heat-sensitive but resisted overnight dialysis.

    Conclusions:

    • Human milk contains factors that positively modulate B cell function.
    • These findings suggest a novel immunological mechanism contributing to the anti-infectious properties of breast milk.
    • Further research into these milk components could inform infant health strategies.

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