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Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
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Malignant Transformation of Dysplastic Vocal Fold Lesions: A Systematic Review and Meta-Analysis
Garret Horton1, Justine Philteos1, R Jun Lin2
1Department of Otolaryngology-Head & Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
JAMA Otolaryngology-- Head & Neck Surgery
|May 16, 2024
Summary
The risk of laryngeal cancer increases with the grade of dysplasia. Moderately and severely dysplastic lesions show a higher likelihood of malignant transformation compared to mildly dysplastic lesions.
Area of Science:
- Otolaryngology
- Oncology
- Pathology
Background:
- Malignant transformation rates and timelines for laryngeal dysplasia vary significantly.
- Accurate prognostication is crucial for managing dysplastic laryngeal lesions.
Purpose of the Study:
- To systematically evaluate the rate and time to malignant transformation of laryngeal dysplasia using the World Health Organization (WHO) classification.
- To provide a quantitative analysis of transformation risks across different dysplasia grades.
Main Methods:
- A comprehensive systematic review and meta-analysis of 18 retrospective cohort studies involving 3243 participants.
- Searched multiple databases (PubMed, MEDLINE, Embase, etc.) up to June 2023 for English-language articles.
- Pooled data using random-effects meta-analysis to determine malignant transformation rates and odds ratios.
Main Results:
- Weighted pooled malignant transformation rates were 10.9% (mild), 23.3% (moderate), and 30.5% (severe) dysplasia.
- Nondysplastic lesions had a 4.5% transformation rate.
- Moderately and severely dysplastic lesions had significantly higher odds of malignant transformation (ORs 2.90 and 3.42, respectively) compared to mild dysplasia.
Conclusions:
- Malignant transformation risk escalates with the grade of laryngeal dysplasia.
- Early and accurate grading of laryngeal dysplasia is essential for risk stratification and patient management.
- Findings support more intensive surveillance for moderate and severe dysplasia.
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