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Updated: Jun 26, 2025
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Determination of mandibular distraction osteogenesis most suitable parameters. An experimental study
Antonio Fuente-Del Campo1, Daniel Reyes-Cureño2
1Division of Plastic, Esthetic and Reconstructive Surgery, Hospital "Dr. Manuel Gea González", Secretaría de Salud.
Background:
Distraction osteogenesis is a process of induced bone generation. Various protocols have been described for the management of the latency period, distraction speed and consolidation period, with greater or lesser success.
Objective:
To better understand the process of mandibular distraction and establish the determining factors and their optimal times.
Material And Methods:
Twenty-seven dogs were studied, which had 54 distractors placed and that underwent unidirectional, bilateral mandibular distraction osteogenesis. The distraction processes were applied using six variants, two for each factor: latency period, distraction period and distraction speed. The changes were examined by means of bone biopsies and X-rays of the area at 0, 7, 14, 21, 45 and 55 days of the process.
Results:
The most efficient osteogenic distraction parameters were a latency period of five days, a consolidation period of six weeks, distraction speed of 1 mm/day for distances of less than 20 mm, and 3 mm/day for longer distances.
Conclusions:
The sequential histological study allowed to observe the appearance of cellular elements (osteocytes, osteoclasts, osteoid matrix, trabeculate, etc.) and their participation in granulation tissue, newly-formed bone and compact mature bone.
