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Related Experiment Video

Updated: May 11, 2026

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

Study protocol: Close Assessment and Testing for Chronic Graft-vs.-Host disease (CATCH).

Joseph Pidala¹, Paul A Carpenter^2,3, Lynn Onstad²

¹Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL, United States of America.

|May 16, 2024

Summary

The Close Assessment and Testing for Chronic GVHD (CATCH) study aims to identify biomarkers for chronic graft-versus-host disease (GVHD) after transplantation. This research will improve understanding and management of this serious immune complication.

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Area of Science:

Immunology
Transplantation Medicine
Biomarker Discovery

Background:

Chronic graft-versus-host disease (GVHD) is a significant complication following allogeneic hematopoietic cell transplantation.
It leads to substantial late morbidity and mortality in transplant recipients.

Purpose of the Study:

To prospectively identify clinical and biologic biomarkers for chronic GVHD onset.
To closely monitor patients pre- and post-transplant to capture GVHD development.
To facilitate collaboration for leveraging the CATCH study resource.

Main Methods:

Prospective, multi-center, longitudinal cohort study design.
Enrollment of patients before hematopoietic cell transplantation.
Collection of comprehensive data including clinical assessments, patient-reported outcomes, biospecimens (blood, saliva, etc.), laboratory tests, and medical records.
Data collection at baseline, every two months for one year, and ongoing chart review.

Main Results:

This report focuses on the study's rationale, design, and methods.
Detailed findings on biomarker identification and clinical outcomes will be reported as the study progresses.

Conclusions:

The CATCH study provides a robust framework for understanding chronic GVHD.
The study aims to improve early detection and management strategies for chronic GVHD.
Collaboration is encouraged to maximize the impact of this research resource.