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  11. Explore The Shared Molecular Mechanism Between Dermatomyositis And Nasopharyngeal Cancer By Bioinformatic Analysis

Explore the shared molecular mechanism between dermatomyositis and nasopharyngeal cancer by bioinformatic analysis

Xiuqin Zhong1, Jingjing Shang1, Rongwei Zhang1

  • 1Department of rheumatology and immunology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Plos One
|May 16, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Dermatomyositis (DM) and nasopharyngeal carcinoma (NPC) share links through viral gene replication and interferon responses. Key genes and hsa-miR-146a offer new diagnostic and treatment strategies for patients with DM and NPC.

Area of Science:

  • Immunology
  • Oncology
  • Virology

Background:

  • Dermatomyositis (DM) is associated with an increased risk of nasopharyngeal carcinoma (NPC).
  • The underlying mechanisms connecting DM and NPC remain unclear.
  • This study investigates the shared pathogenesis between DM and NPC.

Purpose of the Study:

  • To identify key genes and pathways involved in the co-occurrence of DM and NPC.
  • To explore the role of viral gene replication and interferon responses in DM-NPC pathogenesis.
  • To discover potential diagnostic and therapeutic targets for DM complicated by NPC.

Main Methods:

  • Downloaded and analyzed multiple gene expression datasets (GSE46239, GSE142807, GSE12452, GSE53819) from the GEO database.
  • Utilized Weighted Gene Co-expression Network Analysis (WGCNA) to identify disease-related modules.

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  • Performed functional enrichment analysis (ClueGO), differential gene expression (limma), and constructed miRNA-mRNA networks.

    • Main Results:

    • Identified key gene modules positively correlated with both DM and NPC, enriched in negative regulation of viral gene replication.
    • Found overlapping down-regulated differentially expressed genes (DEGs) in DM and NPC also enriched in viral gene replication regulation.
    • Discovered 10 hub genes, primarily regulating viral processes and type I interferon responses, with four genes (GBP1, IFIH1, IFIT3, BST2) demonstrating strong diagnostic performance (AUC>0.8).
    • Observed correlation between key gene expression and macrophage infiltration in both diseases.
    • Identified hsa-miR-146a as a vital regulator in the DM-NPC miRNA-mRNA network.

    Conclusions:

    • Viral gene replication and type I interferon responses are crucial links between DM and NPC.
    • Hub genes and hsa-miR-146a present novel strategies for diagnosing and treating DM patients with NPC.
    • Individuals with persistent viral replication in DM should undergo screening for nasopharyngeal carcinoma.