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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 26, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Bone Metastases.

Gary J R Cook¹, Matthew P Thorpe²

¹From the Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, St. Thomas' Hospital, London, UK.

Cancer Journal (Sudbury, Mass.)

|May 16, 2024

Summary

This summary is machine-generated.

Early detection and monitoring of bone metastases from cancers like breast and prostate are crucial. Advanced molecular imaging agents aid in identifying metastases and assessing treatment effectiveness, including radionuclide therapies.

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Last Updated: Jun 26, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

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Published on: September 9, 2020

Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

Area of Science:

Oncology
Nuclear Medicine
Radiology

Background:

Bone metastases are common in breast and prostate cancer, causing significant morbidity and skeletal-related events.
Effective management requires early detection and accurate monitoring of treatment response.

Purpose of the Study:

To highlight the importance of early detection and monitoring of bone metastases.
To review the role of molecular imaging agents in managing bone metastases and guiding therapy.

Main Methods:

Review of current diagnostic and therapeutic strategies for bone metastases.
Discussion of single-photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging agents.
Exploration of theranostic agents for predicting radionuclide therapy response.

Main Results:

Molecular imaging agents enable sensitive detection of bone metastases.
These agents assist in monitoring response to systemic therapies.
Theranostic agents can confirm target expression and predict treatment outcomes.

Conclusions:

Early and accurate imaging of bone metastases is vital for patient care.
Molecular imaging plays a key role in optimizing cancer treatment strategies.
Theranostic approaches hold promise for personalized radionuclide therapy in bone metastases.