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Association of atherogenic indices with myocardial damage and mortality in COVID-19

Seyda Gunay-Polatkan1, Serhat Caliskan2, Deniz Sigirli3

  • 1Bursa Uludag University Faculty of Medicine, Department of Cardiology, Gorukle/Bursa, Turkey.

Plos One
|May 16, 2024
PubMed

Insights

The triglyceride to HDLc ratio (THR) is linked to heart muscle damage and strongly predicts COVID-19 mortality. Higher THR indicates increased risk in patients with COVID-19.

Area of Science:

  • Cardiology
  • Biochemistry
  • Infectious Diseases

Background:

  • Lipoproteins are crucial for cell membrane stability and defense against microbes.
  • COVID-19 patients frequently exhibit damage to their heart muscle cell membranes.

Purpose of the Study:

  • To investigate the association between atherogenic indices and myocardial damage in COVID-19 patients.
  • To determine the predictive value of atherogenic indices for in-hospital mortality in COVID-19.

Main Methods:

  • Observational, single-center, retrospective study of 783 COVID-19 patients.
  • Collected data on C-reactive protein (CRP), lipids (TC, HDLc, LDLc, triglycerides), cardiac troponin I (cTnI), and ferritin.
  • Calculated various atherogenic indices, including the triglyceride to HDLc ratio (THR).

Main Results:

  • Mortality rate was 15.45%. Non-survivors were older and had significantly higher CRP, cTnI, triglycerides, and atherogenic indices (including THR).
  • Non-survivors showed significantly lower levels of LDLc, HDLc, TC, and albumin.
  • The triglyceride to HDLc ratio (THR) was significantly elevated in non-survivors.

Conclusions:

  • The triglyceride to HDLc ratio (THR) is positively correlated with myocardial damage in COVID-19.
  • THR is a strong predictor of in-hospital mortality for patients with COVID-19.
Abstract

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