Association of atherogenic indices with myocardial damage and mortality in COVID-19

Area of Science:

• Cardiology
• Biochemistry
• Infectious Diseases

Background:

• Lipoproteins are crucial for cell membrane stability and defense against microbes.
• COVID-19 patients frequently exhibit damage to their heart muscle cell membranes.

Purpose of the Study:

• To investigate the association between atherogenic indices and myocardial damage in COVID-19 patients.
• To determine the predictive value of atherogenic indices for in-hospital mortality in COVID-19.

Main Methods:

• Observational, single-center, retrospective study of 783 COVID-19 patients.
• Collected data on C-reactive protein (CRP), lipids (TC, HDLc, LDLc, triglycerides), cardiac troponin I (cTnI), and ferritin.
• Calculated various atherogenic indices, including the triglyceride to HDLc ratio (THR).

Main Results:

• Mortality rate was 15.45%. Non-survivors were older and had significantly higher CRP, cTnI, triglycerides, and atherogenic indices (including THR).
• Non-survivors showed significantly lower levels of LDLc, HDLc, TC, and albumin.
• The triglyceride to HDLc ratio (THR) was significantly elevated in non-survivors.

Conclusions:

• The triglyceride to HDLc ratio (THR) is positively correlated with myocardial damage in COVID-19.
• THR is a strong predictor of in-hospital mortality for patients with COVID-19.