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Prevalence and Risk Factors of Constipation Symptoms among Patients Undergoing Colonoscopy: A Single-Center
Shiori Komori1,2, Junichi Akiyama1, Naoko Tatsuno1
1Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Tokyo, Japan.
Digestion
|May 16, 2024
Summary
Constipation affects one-third of patients undergoing colonoscopy. Many experience refractory symptoms despite medication, highlighting the need to address underlying health conditions and medication use.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Epidemiology
Background:
- Constipation is a prevalent gastrointestinal symptom impacting quality of life and healthcare costs.
- Identifying risk factors for constipation and refractory constipation is crucial for effective patient management.
Purpose of the Study:
- To evaluate the prevalence and independent risk factors of constipation symptoms.
- To identify predictors for refractory constipation symptoms among patients undergoing colonoscopy.
Main Methods:
- Analysis of 8,621 patients who underwent colonoscopy and completed questionnaires over 4.5 years.
- Symptom evaluation using the Gastrointestinal Symptoms Rating Scale.
- Multivariate analysis to determine independent risk factors and predictors.
Main Results:
- Constipation prevalence was 33.3% among eligible patients.
- Independent risk factors included female sex, older age, cerebral stroke, chronic renal failure, ischemic heart disease, diabetes, COPD, benzodiazepine, antiparkinsonian, and opioid use.
- Refractory constipation symptoms were present in 61.4% of patients on medication. Diabetes and irritable bowel syndrome predicted refractory symptoms.
Conclusions:
- Constipation affects one-third of patients, with over half experiencing refractory symptoms despite laxative use.
- Concurrent diseases and polypharmacy are associated with constipation symptoms.
- Further research into managing refractory constipation in patients with comorbidities is warranted.
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