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Related Concept Videos

Proteomics01:33

Proteomics

7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Identification Of Biomarkers And Potential Therapeutic Targets For Pancreatic Cancer By Proteomic Analysis In Two Prospective Cohorts

Identification of biomarkers and potential therapeutic targets for pancreatic cancer by proteomic analysis in two prospective cohorts

Jingjing Lyu1, Minghui Jiang1, Ziwei Zhu1

  • 1Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cell Genomics
|May 16, 2024

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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
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View abstract on PubMed

Summary
This summary is machine-generated.

Early detection of deadly pancreatic cancer (PC) may be possible using blood biomarkers. Researchers identified regenerating family member 1A (REG1A) and REG1B proteins as promising indicators for early pancreatic cancer diagnosis.

Area of Science:

  • Biomarkers and Proteomics
  • Oncology
Keywords:
Mendelian randomizationbiomarkercirculating proteinincident pancreatic cancer

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  • Epidemiology

    • Background:

    • Pancreatic cancer (PC) is a highly lethal malignancy often diagnosed at late stages.
    • Identifying reliable biomarkers for early PC detection is crucial for improving patient outcomes.
    • Blood proteome alterations may offer potential diagnostic indicators for PC.

    Purpose of the Study:

    • To identify novel serum protein biomarkers for the early detection of pancreatic cancer.
    • To investigate the association of specific proteins with incident PC in a prospective cohort.
    • To validate potential biomarkers in an independent dataset and assess causality.

    Main Methods:

    • A nested case-control study within a large prospective cohort of elderly Chinese participants.
    • Proximity extension assay (PEA) was used to analyze 1,463 serum proteins.
    • Replication analysis in the UK Biobank and Mendelian randomization were employed for validation.

    Main Results:

    • Four proteins (REG1A, REG1B, TNF, PLA2G1B) were associated with incident PC (p < 0.005).
    • Regenerating family member 1A (REG1A) and REG1B showed consistent association and increasing effect size closer to diagnosis.
    • Mendelian randomization supported a potential causal role for REG1 proteins in PC development.

    Conclusions:

    • Circulating REG1A and REG1B proteins are promising biomarkers for early pancreatic cancer detection.
    • These REG1 proteins may also represent potential therapeutic targets for PC prevention and treatment.
    • The findings highlight the utility of proteomic analysis in identifying early cancer biomarkers.
    prospective study
    risk stratification