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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
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Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
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During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that...
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Updated: Jun 26, 2025

Antibiotic Dereplication Using the Antibiotic Resistance Platform
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PharmaRedefine: A database server for repurposing drugs against pathogenic bacteria.

Longxiao Yuan1, Jingjing Guo1

  • 1Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao 999097, China.

Methods (San Diego, Calif.)
|May 16, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces PharmaRedefine, an online tool for drug repurposing against pathogenic bacteria. It predicts new uses for FDA-approved drugs by identifying similar protein targets, aiding the fight against antibiotic resistance.

Keywords:
DatabaseDrug repurposingPathogenic Bacteria

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Area of Science:

  • Microbiology
  • Drug Discovery
  • Bioinformatics

Background:

  • Pathogenic bacteria pose a significant global health threat, exacerbated by rising antibiotic resistance.
  • Innovative strategies are crucial for developing new treatments against bacterial infections.
  • Drug repurposing offers a viable avenue for identifying novel antimicrobial therapies.

Purpose of the Study:

  • To develop a computational approach for identifying potential bacterial targets for existing drugs.
  • To introduce PharmaRedefine, an online server facilitating drug repurposing against pathogenic bacteria.
  • To leverage protein-ligand binding pocket similarities for predicting drug-target interactions.

Main Methods:

  • Utilizing sequence and structure alignment algorithms.
  • Performing protein pocket similarity analysis.
  • Integrating these methods into the PharmaRedefine online platform.

Main Results:

  • PharmaRedefine enables prediction of potential bacterial targets for FDA-approved drugs.
  • The server facilitates drug repositioning strategies for combating bacterial infections.
  • Identified potential drug-target interactions for various pathogenic bacteria.

Conclusions:

  • PharmaRedefine is a valuable resource for accelerating drug repurposing efforts against bacterial pathogens.
  • The approach holds promise for discovering new therapeutic applications of existing drugs.
  • This strategy can contribute to overcoming the challenge of antibiotic resistance.