An Ia-positive mouse T-cell clone is functional in presenting antigen to other T cells

In this report we present data demonstrating the endogenous expression of I-region associated (Ia) antigens on a cloned line of mouse T cells, CTLL, as well as transcription of the invariant chain gene in these cells. We demonstrate further that this Ia-bearing T-cell clone, CTLL, can utilize the expressed Ia molecules to present antigen to Ia-restricted antigen-specific T cells.