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Cost-of-Illness of Skin Cancer: A Systematic Review
Annick Meertens1,2,3, Laura Van Coile1,2, Tijs Van Iseghem3
1Department of Dermatology, University Hospital Ghent, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Pharmacoeconomics
|May 16, 2024
Summary
Understanding the economic impact of skin cancer is crucial due to its rising incidence. This review highlights the need for standardized cost-of-illness studies to identify key cost drivers for melanoma and keratinocyte carcinoma.
Area of Science:
- Oncology
- Health Economics
- Public Health
Background:
- Rising incidence of skin cancer necessitates understanding its economic burden.
- Current cost-of-illness studies for skin cancer are fragmented due to diverse methodologies.
- Lack of standardized approaches hinders comprehensive economic impact assessment.
Purpose of the Study:
- Systematically review cost-of-illness studies for melanoma and keratinocyte carcinoma.
- Provide an overview of methodological approaches used in these studies.
- Identify the primary cost drivers associated with skin cancer treatment.
Main Methods:
- Systematic review adhering to 2020 PRISMA guidelines.
- Searched PubMed, Embase, and Web of Science (Dec 2022-Dec 2023).
- Included 45 studies published after 2012, assessing methodological quality.
Main Results:
- 45 studies evaluated over 500,000 patients; 36 focused on melanoma.
- Direct costs were in all studies; indirect costs in only nine.
- Heterogeneity in study populations, methods, and healthcare systems observed.
- Melanoma costs increased with tumor stage; systemic therapy was a key driver in advanced stages.
- No clear cost drivers identified for keratinocyte carcinoma.
Conclusions:
- A standardized study design for skin cancer cost-of-illness research is needed.
- Enhanced comparability and identification of cost drivers will improve decision-making.
- Evidence-based strategies can be developed for effective skin cancer management.
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