Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Steroids reduce complement activation in rheumatoid arthritis.

I Brandslund, N D Peters, L Ejstrup

    International Journal of Tissue Reactions
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Complement C3d is not associated with axial spondyloarthritis and magnetic resonance imaging changes at the sacroiliac joint.

    Scandinavian journal of rheumatology·2021
    Same author

    Highly sensitive quantification of optic neuritis intrathecal biomarker CXCL13.

    Multiple sclerosis and related disorders·2020
    Same author

    Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study.

    Journal of neuroinflammation·2019
    Same author

    Associations between functional polymorphisms and response to biological treatment in Danish patients with psoriasis.

    The pharmacogenomics journal·2017
    Same author

    Disease activity in and quality of life of patients with psoriatic arthritis mutilans: the Nordic PAM Study.

    Scandinavian journal of rheumatology·2017
    Same author

    Cardiac Abnormalities in Adult Patients With Polymyositis or Dermatomyositis as Assessed by Noninvasive Modalities.

    Arthritis care & research·2015
    Same journal

    Effects of D-003 (5-200 mg/kg), a mixture of high molecular weight aliphatic acids from sugarcane wax, on bones and bone cell apoptosis in ovariectomized rats.

    International journal of tissue reactions·2006
    Same journal

    Effect of D-004, a lipid extract from Cuban royal palm fruit, on histological changes of prostate hyperplasia induced with testosterone in rats.

    International journal of tissue reactions·2006
    Same journal

    Pigment epithelium-derived factor is a pericyte mitogen secreted by microvascular endothelial cells: possible participation of angiotensin II-elicited PEDF downregulation in diabetic retinopathy.

    International journal of tissue reactions·2006
    Same journal

    Minodronate, a nitrogen-containing bisphosphonate, inhibits advanced glycation end product-induced vascular cell adhesion molecule-1 expression in endothelial cells by suppressing reactive oxygen species generation.

    International journal of tissue reactions·2006
    Same journal

    Tissue reaction at the implantation of recombinant human bone morphogenetic protein-2 into the skeletal muscle.

    International journal of tissue reactions·2006
    Same journal

    Increasing incidence of melanoma in central Greece: a retrospective epidemiological study.

    International journal of tissue reactions·2006
    See all related articles

    Elevated C3d levels in rheumatoid arthritis (RA) patients decrease with steroid treatment. This indicates that steroids reduce complement activation, a key factor in RA inflammation.

    Area of Science:

    • Immunology
    • Rheumatology
    • Clinical Medicine

    Background:

    • Rheumatoid arthritis (RA) is characterized by inflammation and immune system dysregulation.
    • Elevated plasma concentrations of the complement C3 split product, C3d, are observed in patients with severe active RA.
    • C3d levels show minimal diurnal or circadian variation in individual RA patients.

    Purpose of the Study:

    • To investigate the effect of steroid treatment on plasma C3d levels in RA patients.
    • To determine the relationship between steroid-induced anti-inflammatory effects and complement activation.

    Main Methods:

    • Measurement of plasma C3d, Ritchie index, and pain scores in six RA patients before and during steroid treatment (30 mg prednisolone daily).
    • Monitoring of serum total hemolytic complement activity, complement C3, and C4 levels.

    Related Experiment Videos

  • Analysis of variable changes over a 14-day treatment period.

    • Main Results:

    • Plasma C3d levels decreased significantly during steroid treatment, with a substantial fall within the first 48 hours.
    • The Ritchie index and pain scores also showed a steady decrease.
    • Serum total hemolytic complement activity, C3, and C4 levels did not change significantly.

    Conclusions:

    • Steroid therapy in RA patients is associated with a reduction in complement activation, as evidenced by decreased plasma C3d levels.
    • The anti-inflammatory effects of steroids in RA correlate with diminished complement pathway activity.
    • C3d may serve as a biomarker for monitoring treatment response and complement activation in RA.