Related Experiment Video
Updated: Jun 26, 2025

Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis
Published on: March 15, 2024
Massive infected pancreatic necrosis in an 8-year-old: Endoscopic management
William F Abel1, Varun Kesar2, Reid D Wasserman1
1Virginia Tech Carilion, Department of Internal Medicine Roanoke Virginia USA.
Insights
Pediatric pancreatitis, often caused by medications, can lead to severe complications. Endoscopic pancreatic necrosectomy effectively treated a large walled-off necrotic collection in a young patient, leading to significant clinical improvement.
Area of Science:
- Pediatric Gastroenterology
- Interventional Radiology
- Surgical Pathology
Background:
- Pancreatitis is rare in children, often linked to medications, congenital issues, or critical illness.
- This case involved a pediatric patient with pancreatitis secondary to 6-mercaptopurine treatment.
- The condition progressed to a large walled-off necrotic collection with pelvic extension.
Abstract:
Pancreatitis is a condition much more commonly found in adults, but when diagnosed in the pediatric population, is often due to medications, congenital pathology, and critical illness. This patient had previously undergone treatment with 6-mercaptopurine and presented with pancreatitis that eventually worsened to a walled-off necrotic collection with paracolic extensions reaching the pelvis. Given clinical worsening with development of shock, procedural options for source control were weighed with gastroenterology, pediatric surgery, and interventional radiology, before pancreatic necrosectomy was determined to be the treatment of choice, given the adjacency of the collection to the stomach. A total of three separate endoscopic pancreatic necrosectomy procedures were performed and the patient s clinical status improved greatly, with vast improvement later seen on outpatient imaging. This successful treatment course argues for the efficacy of pancreatic necrosectomy even in very large walled off collections, and most importantly, lead to a positive outcome in this young patient.
Related Concept Videos
Acute Pancreatitis II: Clinical Manifestations and Management
Chronic Pancreatitis II: Collaborative Care
Assessment:
Endoscopic Procedures V: ERCP
Patient...
Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical Interventions for Peptic Ulcer Disease

