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Clinical outcomes for olfactory neuroblastoma
Akira Nakazono1, Hiroaki Motegi2, Masanobu Suzuki1
1Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Frontiers in Oncology
|May 17, 2024
Summary
This study evaluated a treatment protocol for olfactory neuroblastoma (ONB). Endoscopic skull base surgery (ESBS) showed favorable outcomes with lower complication rates and better perioperative data compared to open surgery.
Area of Science:
- Oncology
- Neurosurgery
- Otolaryngology
Background:
- Olfactory neuroblastoma (ONB) is a rare malignant tumor.
- Standard treatment protocols for ONB vary.
- This study evaluates a specific institutional treatment protocol for ONB.
Purpose of the Study:
- To evaluate the outcomes of a specific treatment protocol for olfactory neuroblastoma (ONB).
- To compare the efficacy and perioperative data of endoscopic skull base surgery (ESBS) versus craniotomy combined with ESBS for ONB.
Main Methods:
- Retrospective review of patients with ONB.
- Analysis of survival outcomes and perioperative data.
- Patients treated with ESBS, craniotomy with ESBS, or chemoradiotherapy (CRT).
Main Results:
- Favorable survival rates: 5-year overall survival 92.9%, 10-year 82.5%.
- Endoscopic skull base surgery (ESBS) group showed significantly shorter operating times, ambulation, hospitalization, and less blood loss.
- ESBS group had lower complication rates and better perioperative outcomes.
Conclusions:
- The evaluated treatment protocol for ONB yields favorable outcomes.
- Endoscopic skull base surgery (ESBS) is a safe and effective approach for select ONB cases.
- ESBS offers advantages in terms of reduced complications and improved perioperative data compared to open approaches.
