Hyperbaric oxygen therapy: future prospects in regenerative therapy and anti-aging

Area of Science:

• Biomedical Engineering
• Regenerative Medicine
• Gerontology

Background:

• Hyperbaric Oxygen Therapy (HBOT) involves administering 100% oxygen at elevated atmospheric pressures.
• HBOT is recognized as a valuable supplementary treatment for diverse clinical and pathological conditions.
• Its efficacy stems from enhanced tissue oxygenation and improved oxygen bioavailability.

Purpose of the Study:

• To explore the multifaceted therapeutic applications of HBOT.
• To elucidate the physiological and genetic mechanisms underlying HBOT's regenerative effects.
• To assess HBOT's potential in anti-aging and regenerative therapies.

Main Methods:

• Review of existing clinical applications and research findings on HBOT.
• Analysis of HBOT's impact on physiological processes like vascularization, angiogenesis, and collagen production.
• Investigation of HBOT's genetic-level effects, including gene expression modulation, senescence delay, and telomere maintenance.

Main Results:

• HBOT demonstrates significant benefits in wound healing, burn treatment, and managing tissue necrosis.
• The therapy actively promotes vascularization, stimulates angiogenesis, and augments collagen synthesis.
• HBOT influences cellular processes by altering gene expression, delaying senescence, and potentially enhancing telomere length.

Conclusions:

• HBOT is a promising therapeutic modality with broad applications in tissue regeneration.
• The therapy exhibits potential for anti-aging interventions by targeting cellular aging mechanisms.
• Further research into HBOT's genetic and physiological effects could unlock its full regenerative potential.