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Advances in preclinical approaches for intravesical therapy of bladder cancer

Sreekanth Reddy Obireddy1,2, Wing-Fu Lai2,3

  • 1Department of Chemistry, Sri Krishnadevaraya University, Ananthapur, India.

Current Opinion in Urology
|May 17, 2024
PubMed
Abstract

Insights

New intravesical therapies show promise for bladder cancer treatment. Advances in drug delivery systems and immunotherapy offer improved efficacy and reduced side effects, enhancing patient outcomes.

Area of Science:

  • Urology
  • Oncology
  • Nanotechnology

Background:

  • Bladder cancer treatment presents significant clinical challenges.
  • Intravesical therapy is a key modality requiring continuous innovation.

Purpose of the Study:

  • To explore novel strategies for bladder cancer treatment.
  • To address challenges and opportunities in intravesical therapy.

Main Methods:

  • Review of preclinical advancements in intravesical therapy.
  • Analysis of novel drug delivery systems and carriers.
  • Evaluation of innovative imaging techniques for targeted therapy.

Main Results:

  • Immunotherapy with protein aggregates demonstrates superior efficacy over Bacillus Calmette-Guerin.
  • Advanced drug delivery systems, including nanoparticles, enhance efficiency and minimize adverse reactions.
  • Near-infrared fluorescence probes and nano-transformers facilitate real-time detection and targeted treatment.

Conclusions:

  • Recent progress in drug delivery technologies offers promising solutions for bladder cancer.
  • Optimizing these technologies is crucial for improving patient outcomes.
  • Advancements facilitate the clinical translation of various treatment modalities.

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