Related Experiment Video
Updated: Jul 1, 2026
09:01
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
10.0K
Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary
Laëtitia Elies1, Elise Guillaume2, Mathilde Gorieu3
1Charles River Laboratories, Saint-Germain-Nuelles, France.
Toxicologic Pathology
|May 17, 2024
Summary
This study analyzed 1600 control C57BL/6J mice over 18 months, finding high survival rates and common non-tumoral causes of death. It also identified frequent benign tumors, particularly in females, and noted changes in lesion incidence over time.
Area of Science:
- Toxicology and Carcinogenicity Studies
- Laboratory Animal Science
- Pathology
Background:
- C57BL/6J mice are a standard model for carcinogenicity testing.
- Historical control data is crucial for interpreting study findings.
- Long-term health data in untreated mice is essential for establishing baseline health parameters.
Purpose of the Study:
- To establish a robust historical control dataset for C57BL/6J mice.
- To determine survival rates, causes of death, and incidence of spontaneous lesions in mice.
- To analyze trends in tumor and non-tumoral findings over time.
Main Methods:
- Retrospective analysis of 1600 untreated C57BL/6J mice.
- Data collected from 16 carcinogenicity assays (2003-2021).
- Mice were observed for 18 months under controlled conditions.
Main Results:
- High survival rates (81%-85%) with primary causes of death being non-tumoral (dermatitis, thrombosis).
- Benign tumors were more common than malignant ones; females had higher tumor incidence.
- Common tumors included pituitary adenoma (females), lymphoma, and bronchioloalveolar/harderian gland adenomas. Systemic amyloidosis was the most frequent non-tumoral lesion.
Conclusions:
- This study provides comprehensive historical control data for 18-month-old C57BL/6J mice.
- Trends indicate increasing lymphoma and pituitary adenoma incidence and decreasing amyloidosis over time.
- These findings enhance the understanding of spontaneous lesions in this widely used animal model.
Related Concept Videos
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...