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[Nuclease-antibodies in infections with Serratia marcescens (author's transl)]
Immunitat Und Infektion
|August 1, 1979
Abstract:
A total of 467 presumable healthy men of age eighteen yielded titres of anti-serratia-nuclease that ranged from 1:4 to 1:6. One third of 56 patients, who had been infected with Serratia marcescens (urinary-, wound-, respiratory-infections, and bacteremia) yielded raised anti-nuclease titres, which amounted maximaly 1:16. The diagnostic utility of this serological test was discussed.
Insights
Healthy men showed normal anti-serratia-nuclease antibody levels. A third of patients with Serratia marcescens infections had elevated titres, suggesting diagnostic potential for this serological test.
Area of Science:
- Microbiology
- Immunology
- Clinical Diagnostics
Context:
- Serratia marcescens is an opportunistic pathogen causing various infections.
- Assessing immune response to S. marcescens infections is crucial for diagnosis.
- Antibody titres against bacterial enzymes can indicate infection and immune status.
Purpose:
- To evaluate the diagnostic utility of anti-serratia-nuclease antibody titres.
- To determine baseline antibody levels in a healthy population.
- To assess antibody titres in patients with S. marcescens infections.
Summary:
- A study of 467 healthy men aged 18 found anti-serratia-nuclease antibody titres ranging from 1:4 to 1:6.
- Among 56 patients with S. marcescens infections (urinary, wound, respiratory, bacteremia), one-third exhibited elevated anti-nuclease titres, reaching a maximum of 1:16.
- The findings suggest that anti-serratia-nuclease titres may serve as a useful serological marker.
Impact:
- Provides insights into the serological response to Serratia marcescens infections.
- Highlights the potential of anti-nuclease titres as a diagnostic tool.
- Contributes to understanding the clinical utility of serological tests in infectious diseases.