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Related Concept Videos

Cattell's 16 Personality Factors01:24

Cattell's 16 Personality Factors

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Raymond Cattell's trait theory offers a structured framework for understanding personality by distinguishing between two critical traits: surface and source traits. Surface traits are observable patterns of behavior, such as indecisiveness, anxiety, and irrational fears. These traits are less stable, varying across situations and over time. This means that they are less helpful in understanding the deeper aspects of an individual's personality.
In contrast, source traits are the...
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There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
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The earliest recorded discussion of the basic structure of matter comes from ancient Greek philosophers. Leucippus and Democritus argued that all matter was composed of small, finite particles that they called atomos, meaning “indivisible.” Later, Aristotle and others came to the conclusion that matter consisted of various combinations of the four “elements” — fire, earth, air, and water — and could be infinitely divided. Interestingly, these philosophers...
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After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
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Ionic Radii03:10

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[Present status and clinical therapy of pancreatic diseases].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·1992
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Reptilian viruses: adenovirus-like agent isolated from royal python (Python regius).

Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B·1992
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Specific stimulation by estradiol of tissue-type plasminogen activator production in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor cells.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·1992
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Related Experiment Video

Updated: Feb 16, 2026

Promoting 3-D Aggregation of FACS Purified Thymic Epithelial Cells with EAK 16-II/EAKIIH6 Self-assembling Hydrogel
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[VP 16-213].

M Ogawa

    Gan No Rinsho. Japan Journal of Cancer Clinics
    |May 1, 1985
    PubMed
    Summary

    Oral VP 16-213 (VP 16) shows significant efficacy in treating non-Hodgkin lymphoma (NHL) and small cell lung cancer (SCLC). This chemotherapy agent demonstrates notable activity and lacks cross-resistance to standard NHL therapies.

    Area of Science:

    • Oncology
    • Pharmacology

    Context:

    • Non-Hodgkin lymphoma (NHL) and small cell lung cancer (SCLC) are significant clinical challenges.
    • Evaluating novel therapeutic agents is crucial for improving patient outcomes.

    Purpose:

    • To assess the efficacy and activity of oral VP 16-213 (VP 16) in patients with NHL and SCLC.
    • To determine the response rates and survival outcomes associated with VP 16 in these hematologic and thoracic malignancies.

    Summary:

    • Phase II-III trials investigated oral VP 16 in heavily pretreated NHL patients, achieving a 31% overall response rate (CR+PR) in one arm and a 95% response rate (CR+PR) in another.
    • In small cell lung cancer (SCLC) patients, a combination regimen including VP 16 resulted in complete remission (CR) in a significant proportion of patients with limited (LD) and extensive disease (ED).

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  • Median survival for CR patients in SCLC exceeded one year, indicating substantial clinical benefit.

    • Impact:

    • Oral VP 16 demonstrates significant therapeutic activity in both NHL and SCLC.
    • The drug exhibits a lack of cross-resistance to conventional therapies used for NHL, suggesting its potential as a valuable treatment option.
    • These findings support the further investigation and clinical application of oral VP 16 in managing these cancers.