Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Hematopoiesis01:21

Hematopoiesis

5.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.2K
Production of Formed Elements01:34

Production of Formed Elements

1.4K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
1.4K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

4.0K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations.

Nature genetics·2026
Same author

Preclinical response of uveal melanomas to the velcrin compound, BAY 2666605.

Molecular cancer therapeutics·2026
Same author

Aneuploidy sensitizes cells to SREBP-pathway inhibition in squamous cell carcinoma.

bioRxiv : the preprint server for biology·2026
Same author

A Roadmap to Transform Lung Cancer Outcomes: Priorities in Biology, Therapeutic Innovation, Early Detection, Prevention, and Interception.

Cancer discovery·2026
Same author

Avian Metapneumovirus: Virology, Epidemiology, and Insights from a Comparative Analysis with Human Metapneumovirus-A Review.

Biomolecules·2026
Same author

Osteosarcoma cells promote intracellular iron detoxification to mitigate GPX4-mediated ferroptosis.

Cancer gene therapy·2026
Same journal

Clinical validation of tissue and liquid companion diagnostics for BRAF V600E detection in non-small cell lung cancers from the PHAROS study.

Cancer research communications·2026
Same journal

Comprehensive Profiling of Cell Surface Proteins in Testicular Germ Cell Tumors.

Cancer research communications·2026
Same journal

Tissue context shapes distinct premalignant outcomes in a HPV16 E6/E7-mutant Pik3ca transgenic mouse model.

Cancer research communications·2026
Same journal

Association of Cumulative Proton Pump Inhibitor Use with Prostate Cancer Risk and Outcomes: A Population-Based Cohort Study.

Cancer research communications·2026
Same journal

A phase 1b study of chemo-immunotherapy with pegylated liposomal doxorubicin and Pembrolizumab in estrogen receptor positive metastatic breast cancer.

Cancer research communications·2026
Same journal

DNA Methyltransferase Inhibition Prevents Platinum-Induced Ovarian Cancer Stem Cell Enrichment.

Cancer research communications·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2025

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy
17:08

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

Published on: August 6, 2014

13.2K

Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion.

Jong Hyuk Kim1,2,3,4,5,6,7, Ashley J Schulte1,2,3, Aaron L Sarver1,3,8

  • 1Animal Cancer Care and Research Program, University of Minnesota, St Paul, Minnesota.

Cancer Research Communications
|May 17, 2024
PubMed
Summary
This summary is machine-generated.

Canine hemangiosarcomas create a unique microenvironment that supports blood cell growth and differentiation. This suggests these aggressive tumors may promote the development of other blood-related cancers.

More Related Videos

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

13.4K
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

6.9K

Related Experiment Videos

Last Updated: Jun 26, 2025

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy
17:08

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

Published on: August 6, 2014

13.2K
Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

13.4K
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

6.9K

Area of Science:

  • Comparative oncology
  • Cancer biology
  • Hematopoiesis

Background:

  • Hemangiosarcoma (canine) and angiosarcoma (human) are aggressive, metastatic soft-tissue sarcomas.
  • These tumors originate from blood vessel-forming cells and feature disorganized vascular spaces.

Purpose of the Study:

  • To define the molecular programs enabling the tumor microenvironment for canine hemangiosarcoma and human angiosarcoma.
  • To understand how these sarcomas support their own progression and potentially influence hematopoietic tumors.

Main Methods:

  • Utilized dog-in-mouse hemangiosarcoma xenografts to model tumor characteristics.
  • Performed functional analyses and gene expression profiling on xenograft models.

Main Results:

  • Xenografts mimicked the aggressive, angiogenic nature of primary tumors.
  • Hemangiosarcoma cells induced myeloid hyperplasia and supported hematopoietic progenitor expansion and differentiation.
  • Gene expression revealed cytokine production by tumor cells regulating stromal cells.

Conclusions:

  • Canine hemangiosarcomas possess molecular programs that provide hematopoietic support.
  • These properties facilitate stromal reactions, suggesting a role in promoting hematopoietic tumor growth.
  • Similar mechanisms may be involved in human angiosarcoma progression.