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Generalizing Diffusion Tensor Imaging of the Physis and Metaphysis
Katherine L Luo1, Laura Santos2, Rumana Tokaria2
1Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Journal of Magnetic Resonance Imaging : JMRI
|May 17, 2024
Summary
Diffusion tensor imaging (DTI) of the pediatric physis cartilage demonstrates high reproducibility across various imaging and analysis settings, offering a promising tool for predicting height potential.
Area of Science:
- Biomedical Imaging
- Orthopedic Research
- Pediatric Endocrinology
Background:
- Current methods for predicting height potential lack accuracy.
- Magnetic resonance imaging (MRI) of physeal cartilage shows promise but requires evaluation across diverse imaging setups.
Purpose of the Study:
- To assess the variability of diffusion tensor imaging (DTI) of the distal femur's physis and metaphysis (DTI-P/M).
- To evaluate DTI-P/M variability across different MRI scanners, imaging parameters, tractography software, and resolutions.
Main Methods:
- Prospective study involving eleven healthy subjects (5 males, 6 females, ages 10-16.94).
- Utilized 3T MRI with DTI single-shot echo-planar sequences.
- Analyzed DTI tract measurements using Bland-Altman, Spearman correlation, linear regression, and Shapiro-Wilk tests.
Main Results:
- DTI tract values exhibited low variability across different imaging and analysis settings.
- Strong correlation (ρ=0.93) observed in vendor-to-vendor comparisons, with minimal bias.
- Different voxel sizes and gap sizes showed minimal impact on DTI values, maintaining strong correlations.
Conclusions:
- Diffusion tensor imaging of the pediatric physis cartilage demonstrates high reproducibility.
- The technique is reliable across various imaging and analytical parameters, supporting its clinical application.
