Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cryptococcal Meningitis

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A cysteine-rich domain of the <i>Cryptococcus neoforman</i>s Cuf1 transcription factor is required for high copper stress sensing and fungal virulence.

mBio·2026

Same author

Closing the gap on antifungal resistance.

Nature medicine·2026

Same author

Multisystem <i>Lomentospora prolificans</i> progression on fosmanogepix despite <i>in vitro</i> activity: a call for expanding clinical research on novel antifungals.

ASM case reports·2026

Same author

Temperature and genetic background drive mobilization of diverse transposable elements in a global human fungal pathogen.

PLoS genetics·2026

Same author

In vitro evidence to support amphotericin B and flucytosine combination therapy for talaromycosis.

PLoS neglected tropical diseases·2025

Same author

Vaccine-Mediated Protection of Mice Against African and Asian Clinical Strains of <i>Cryptococcus neoformans</i>.

Journal of fungi (Basel, Switzerland)·2025

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

The Rabbit Model of Cryptococcal Meningitis.

Charles Giamberardino¹, John R Perfect²

¹Duke University School of Medicine, Department of Medicine, Division of Infectious Diseases, Durham, NC, USA. charles.giamberardino@duke.edu.

Methods in Molecular Biology (Clifton, N.J.)

|May 17, 2024

Summary

Cryptococcal meningitis (CM) research benefits from a robust rabbit model. This model allows detailed study of fungal infections in the central nervous system (CNS) and antifungal drug efficacy.

Keywords:

Cryptococcus Drug testing Meningitis Rabbit model Virulence

More Related Videos

A Rat Model of EcoHIV Brain Infection

A Rat Model of EcoHIV Brain Infection

Published on: January 21, 2021

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Published on: March 22, 2024

Related Experiment Videos

Last Updated: Jul 7, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

A Rat Model of EcoHIV Brain Infection

A Rat Model of EcoHIV Brain Infection

Published on: January 21, 2021

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Published on: March 22, 2024

Area of Science:

Infectious Diseases
Mycology
Neuroscience

Background:

Cryptococcal meningitis (CM) is a serious fungal infection of the central nervous system (CNS).
Cryptococcus yeast invades the CNS, often due to immune system dysregulation.
Animal models are crucial for studying CM pathogenesis and treatment.

Purpose of the Study:

To highlight the utility of the rabbit model for Cryptococcal meningitis research.
To detail the methods and applications of the rabbit model in understanding CM.

Main Methods:

The rabbit model involves immune suppression followed by direct CNS infection with Cryptococcus yeast.
Cerebrospinal fluid (CSF) is repeatedly sampled for analysis.
Analyses include quantifying fungal burden, measuring drug levels, and profiling immune responses.

Main Results:

The rabbit model provides a well-established platform with over 40 years of data.
It allows for in-depth study of host-pathogen interactions in the CNS.
The model facilitates evaluation of antifungal therapeutic efficacy.

Conclusions:

The rabbit model is a robust experimental system for advancing CM research.
It enables comprehensive investigation of Cryptococcus cellular behavior within the CNS.
This model is vital for developing new strategies against fungal meningitis.