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Related Concept Videos

Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
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Delayed Presentation of IRAK4 Deficiency

Maria A Sacta1, Juhee Lee2

  • 1Allergy-Immunology Division, Children's Hospital of Philadelphia, Philadelphia, PA, USA. sactam@chop.edu.

Journal of Clinical Immunology
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No abstract available in PubMed .

Keywords:
IRAK4 DeficiencyMeningitisPrimary Immunodeficiency

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