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Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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CRISPR01:59

CRISPR

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Updated: Jun 26, 2025

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
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Microbial Synthetic Epigenetic Tools Design and Applications.

Irene Komera1, Xiulai Chen1, Liming Liu1

  • 1School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China.

ACS Synthetic Biology
|May 17, 2024
PubMed
Summary

Synthetic epigenetics in microbes enables new synthetic biology tools for reversible gene control. This review covers advancements, challenges, and future directions for epigenetic gene regulation in biotechnology.

Keywords:
DNA methylationepigeneticsgene regulationgenetic circuitssynthetic biology

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Area of Science:

  • Microbial synthetic biology
  • Epigenetics
  • Gene regulation

Background:

  • Synthetic epigenetics offers reversible gene control without DNA alteration.
  • Limited understanding and analysis tools hinder epigenetic applications in biotechnology.

Purpose of the Study:

  • To review advancements in epigenetic-based synthetic gene regulatory tools.
  • To examine strategies for constructing stable epigenetic circuits.
  • To discuss challenges and perspectives in synthetic epigenetic tool development.

Main Methods:

  • Literature review of transcriptional and post-transcriptional epigenetic tools.
  • Analysis of strategies for epigenetic circuit construction.
  • Discussion of current challenges and future outlook.

Main Results:

  • Exploration of epigenetic tools at transcriptional and post-transcriptional levels.
  • Examination of strategies for controllable and stable epigenetic gene regulation.
  • Identification of challenges and future perspectives in the field.

Conclusions:

  • Epigenetic-based synthetic gene regulation holds promise for microbial biotechnology.
  • Further research is needed to overcome current limitations and advance synthetic epigenetic tools.