Renal disease associated with multiple sclerosis: A narrative review

Area of Science:

• Neurology
• Nephrology
• Immunology

Background:

• Multiple sclerosis (MS) is a chronic autoimmune neurological disorder affecting the central nervous system.
• Clinical management of MS primarily focuses on neurological symptoms, but a growing body of evidence suggests a connection with renal disease.
• Understanding this association is crucial for comprehensive patient care.

Purpose of the Study:

• To provide a comprehensive overview of the current knowledge on the association between multiple sclerosis and renal disease.
• To explore shared risk factors, pathophysiological links, and the impact of MS on kidney function.
• To review diagnostic challenges, treatment options, and the effect on quality of life.

Main Methods:

• This study is a narrative review of existing literature.
• It synthesizes information on the pathophysiology of MS and various types of renal disease.
• The review analyzes studies investigating the relationship between these two conditions.

Main Results:

• There is a complex interplay between MS and renal disease, with potential shared risk factors and pathophysiological links.
• Renal complications can significantly impact the quality of life for individuals with MS.
• Diagnostic and treatment strategies for renal disease in MS patients require specific consideration.

Conclusions:

• The association between multiple sclerosis and renal disease is significant and warrants further investigation.
• Integrated approaches to managing both neurological and renal aspects are essential for improving patient outcomes.
• Further research is needed to elucidate specific mechanisms and optimize therapeutic interventions.