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Updated: Jul 8, 2026

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Published on: May 12, 2011
Pearls & Oy-sters: A Challenging Optic Neuropathy-What Not to Miss in Optic Nerve Sheath Enhancement
Isabel Vidal1, Ana Patrícia Antunes1, Carlos Morgado1
1From the Divisions of Neurology (N.S., A.P.A., L.A.), Neurosurgery (N.S.), and Neuropathology (R.R.), Department of Neurosciences and Mental Health, and Neuroradiology (C.M.), Hospital de Santa Maria, Centro Hospitalar Universitário de Lisboa Norte, Lisbon; and Centro de Estudos Egas Moniz, Faculdade de Medicina (A.P.A., L.A.), Universidade de Lisboa, Lisbon, Portugal.
Abstract:
Optic neuropathies include a wide range of disorders from ischemic, toxic, demyelinating, or inflammatory processes with acute/subacute onset to more gradual compressive or genetic etiologies. Accurate clinical history and multimodality optic nerve imaging including MRI and optical coherence tomography have greatly improved the diagnosis of patients with optic neuropathies. We report a case of a woman with severe monocular visual acuity deficit. Optic nerve sheath enhancement seen on MRI led to a broad differential diagnosis including demyelinating causes, optic nerve sheath meningioma (ONSM), tuberculosis, and sarcoid optic neuropathy. Lack of response to treatment with steroids or plasmapheresis led to biopsy, which confirmed the diagnosis of ONSM.
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