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Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
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Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

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Antihypertensive medication and dementia risk in patients with hypertension: A nationwide population-based study

Chih-Ying Lin1, Pei-Hsien Chen2, Chiu-Lin Tsai3

  • 1Department of Chinese Traumatology Medicine, China Medical University Hospital, Taichung 40402, Taiwan.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|May 17, 2024
PubMed

Insights

Hypertension significantly increases dementia risk. Antihypertensive medications (AHMs) and traditional Chinese medicine (TCM) were found to lower dementia incidence in hypertensive patients, suggesting potential protective effects.

Area of Science:

  • Neurology
  • Cardiology
  • Gerontology

Background:

  • Hypertension is a prevalent condition with suspected links to cognitive decline.
  • Limited evidence exists regarding the direct impact of hypertension on dementia risk and the role of treatments.

Purpose of the Study:

  • To investigate the association between hypertension and the risk of developing dementia.
  • To determine if antihypertensive medications (AHMs) and traditional Chinese medicine (TCM) reduce dementia incidence in hypertensive individuals.

Main Methods:

  • Retrospective cohort study and case-control study using Taiwan's National Health Insurance Research Database (2000-2016).
  • Analysis included 587,762 matched participants to assess dementia risk in hypertensive versus non-hypertensive groups.
  • Examined the effect of specific AHMs (ARBs, CCBs, diuretics) and TCM on dementia incidence.

Main Results:

  • Hypertension was associated with a significantly higher risk of all-cause dementia, Alzheimer's disease, and vascular dementia (aHR, 2.86).
  • Angiotensin II receptor blockers (aHR, 0.55), calcium channel blockers (aHR, 0.76), and diuretics (aHR, 0.93) significantly decreased dementia incidence.
  • Traditional Chinese Medicine use was also linked to a lower incidence of newly diagnosed dementia in hypertensive patients (aHR, 0.90).

Conclusions:

  • Hypertension is a significant risk factor for dementia.
  • Antihypertensive medications, specifically ARBs, CCBs, and diuretics, demonstrate a protective effect against dementia.
  • Traditional Chinese Medicine may also play a role in reducing dementia incidence among hypertensive patients.

Keywords:
Alzheimer’s diseaseAntihypertension medicationDementiaHypertensiontraditional Chinese medicine

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