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Emerging treatments in HER2-positive advanced breast cancer: Keep raising the bar

Elisa Agostinetto1, Giuseppe Curigliano2, Martine Piccart1

  • 1Oncology Department, Institut Jules Bordet and l'Université Libre de Bruxelles (U.L.B.), Hôpital Universitaire de Bruxelles (HUB), Brussels, Belgium.

Cell Reports. Medicine
|May 17, 2024
PubMed

Insights

Survival for HER2-positive breast cancer patients is improving due to new treatments targeting HER2, HER3, and other pathways. Research focuses on overcoming resistance and exploring novel agents for better patient outcomes.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Human epidermal growth factor receptor 2 (HER2)-positive breast cancer treatment has seen significant advancements.
  • Improved outcomes necessitate novel therapeutic strategies to overcome treatment resistance.

Purpose of the Study:

  • To review the evolving treatment landscape for HER2-positive breast cancer.
  • To highlight emerging therapies and future perspectives in managing this disease.

Main Methods:

  • Literature review of current and emerging treatments for HER2-positive breast cancer.
  • Analysis of therapeutic targets including HER2, HER3, PD-(L)1, CTLA4, NKG2A, AKT, PI3K, estrogen receptors, and CDK4/6.

Main Results:

  • Significant survival improvements observed in patients with HER2-positive breast cancer.
  • A diverse range of novel therapeutic targets are being explored to enhance treatment efficacy.
  • Emerging agents are poised to expand treatment options in the near future.

Conclusions:

  • The treatment of HER2-positive breast cancer is rapidly evolving with a focus on targeted therapies.
  • Overcoming resistance mechanisms remains a critical area for new drug development.
  • Future perspectives involve a multi-targeted approach for improved patient survival and outcomes.
Keywords:
HER2-positive breast canceranti-HER2 treatmentsantibody-drug conjugatesbispecific antibodiesimmunotherapy

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