Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

202
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
202
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

217
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
217
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

183
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
183
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

135
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
135
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

203
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
203
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

153
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
153

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms.

Nature communications·2026
Same author

[High-flow oxygen in acute hypoxemic respiratory failure: no improved survival but clinically relevant? : Commentary on the SOHO trial].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026
Same author

From "Bridge to Decision" to a "Decision to Bridge".

Journal of cardiothoracic and vascular anesthesia·2026
Same author

Early mechanical reperfusion in high-risk pulmonary embolism supported by venoarterial extracorporeal membrane oxygenation: a multicenter international cohort study.

American journal of respiratory and critical care medicine·2026
Same author

[Non-invasive respiratory support for acute respiratory failure with focus on high-flow oxygen therapy and non-invasive Ventilation].

Pneumologie (Stuttgart, Germany)·2026
Same author

The dilemma of sepsis bundle care.

Intensive & critical care nursing·2026

Related Experiment Video

Updated: Jun 26, 2025

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

2.8K

[COVID-19 in the intensive care unit].

André P Becker, Sebastian Mang, Torben Rixecker

    Pneumologie (Stuttgart, Germany)
    |May 17, 2024
    PubMed
    Summary

    Acute respiratory distress syndrome (ARDS) and COVID-19-associated ARDS (C-ARDS) share similar pathophysiology, impacting the blood-air barrier. Current intensive care treatments focus on organ support and preventing complications for both conditions.

    Area of Science:

    • Intensive care medicine
    • Pulmonology
    • Critical care

    Background:

    • Acute respiratory distress syndrome (ARDS) and acute respiratory failure (ARF) have posed significant clinical challenges for over 50 years.
    • Therapeutic options for ARDS/ARF are primarily supportive, focusing on organ function and preventing iatrogenic harm.
    • The emergence of SARS-CoV-2 has led to a rise in COVID-19-associated ARDS (C-ARDS), presenting similar pathophysiological mechanisms to classical ARDS.

    Purpose of the Study:

    • To summarize current intensive care unit (ICU) treatment strategies for acute respiratory failure (ARF) and ARDS.
    • To highlight the similarities in pathophysiology and treatment between classical ARDS and C-ARDS.
    • To provide an overview of supportive care and complication prevention in ARDS management.

    Main Methods:

    More Related Videos

    Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit
    05:56

    Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit

    Published on: September 6, 2024

    2.1K
    An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
    07:16

    An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

    Published on: November 30, 2022

    3.2K

    Related Experiment Videos

    Last Updated: Jun 26, 2025

    Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
    09:36

    Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

    Published on: September 24, 2020

    2.8K
    Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit
    05:56

    Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit

    Published on: September 6, 2024

    2.1K
    An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
    07:16

    An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

    Published on: November 30, 2022

    3.2K
    • Review of existing literature and clinical guidelines on ARDS and C-ARDS treatment.
    • Summary of pathophysiological similarities between classical ARDS and C-ARDS.
    • Focus on intensive care unit (ICU) management strategies.

    Main Results:

    • Both classical ARDS and C-ARDS involve inflammation leading to disruption of the blood-air barrier.
    • Treatment strategies for both conditions are centered on organ function support and prevention of secondary damage.
    • Intensive care interventions aim to mitigate the effects of severe lung injury.

    Conclusions:

    • The pathophysiological pathways of classical ARDS and C-ARDS are fundamentally alike.
    • Effective management of ARDS and C-ARDS relies on supportive care within the ICU setting.
    • Preventing therapy-induced complications remains a critical aspect of treating patients with severe respiratory failure.