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Androcin 18-1, a novel scorpion-venom peptide, shows a potent antitumor activity against human U87 cells via inducing

Kai Wang1, Tienthanh Nguyen2, Yihan Gao1

  • 1Department of Pulmonary and Critical Care Medicine, Zhujiang Hospital, Southern Medical University, 510280, Guangzhou, China.

Insect Biochemistry and Molecular Biology
|May 17, 2024
PubMed

Insights

Androcin 18-1 from scorpion venom shows potential as an anticancer drug. This study details how it inhibits glioblastoma cell growth and migration, offering hope for new glioblastoma treatments.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Toxicology

Background:

  • Scorpion venom contains anticancer compounds.
  • Androcin 18-1 from Androctonus bicolor venom has an unknown bioactivity.
  • Glioblastoma is an aggressive brain tumor with limited treatment options.

Purpose of the Study:

  • To elucidate the antitumor mechanism of Androcin 18-1.
  • To investigate the effects of Androcin 18-1 on human U87 glioblastoma cells.
  • To assess the potential of Androcin 18-1 for glioblastoma drug development.

Main Methods:

  • Transcriptome analysis to identify Androcin 18-1.
  • Cell proliferation and apoptosis assays.
  • Cell membrane disruption, ROS accumulation, and mitochondrial dysfunction assessments.
  • Cell migration assays, cytoskeleton, and MMPs/TIMPs expression analysis.

Main Results:

  • Androcin 18-1 inhibits U87 glioblastoma cell proliferation.
  • It induces apoptosis via cell membrane disruption, ROS accumulation, and mitochondrial dysfunction.
  • Androcin 18-1 suppresses cell migration by affecting cytoskeleton and MMPs/TIMPs expression.

Conclusions:

  • Androcin 18-1 exhibits significant antitumor activity against glioblastoma.
  • Its mechanism involves inducing cell death and inhibiting migration.
  • Androcin 18-1 is a promising candidate for glioblastoma drug development.
Keywords:
Androcin 18−1Anticancer peptideMembranolysisMitochondrial dysfunction

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