Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenergic Agonists: Direct-Acting Agents01:30

Adrenergic Agonists: Direct-Acting Agents

Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.
These agents can be classified...
Adrenergic Agonists: Indirect-Acting Agents01:25

Adrenergic Agonists: Indirect-Acting Agents

Indirect-acting adrenergic agonists potentiate the effects of endogenous catecholamines through different mechanisms without directly binding to adrenoceptors.
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...
Adrenergic Agonists: Chemistry and Structure-Activity Relationship01:16

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase, which converts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lower Urinary Tract Symptoms as an Indicator of Occult Neurologic Disease: A System-first Framework for Urologic Practice.

Current urology reports·2026
Same author

Endogenous vasopressin and vasopressin receptor 2 in bladder as anti-diuretic / anti-spasmodic targets for the treatment of multifactorial nocturia.

Continence (Amsterdam, Netherlands)·2026
Same author

Are There Potential New Therapeutic Avenues for Treating Idiopathic Nocturia? ICI-RS 2025.

Neurourology and urodynamics·2025
Same author

Phenotyping Overactive Bladder-Part 1: Are There Different Types of Urgency and Can They be Translated to Clinical, Urodynamic and Radiological Phenotyping? ICI-RS 2025.

Neurourology and urodynamics·2025
Same author

A rapid method of evaluating cytotoxic drug efficacy using sub-cellular fluctuation imaging.

Scientific reports·2025
Same author

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI-RS 2025.

Neurourology and urodynamics·2025

Related Experiment Video

Updated: Jun 25, 2026

Genetic Incorporation of Biosynthesized L-dihydroxyphenylalanine DOPA and Its Application to Protein Conjugation
10:24

Genetic Incorporation of Biosynthesized L-dihydroxyphenylalanine DOPA and Its Application to Protein Conjugation

Published on: August 24, 2018

7.9K

High-Performance Dopamine-Based Supramolecular Bio-Adhesives.

Maximilian J L Hagemann1, Lewis Chadwick1, Marcus J Drake2

  • 1School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.

Macromolecular Rapid Communications
|May 17, 2024
PubMed
Summary

New supramolecular polymers based on dopamine offer superior wound closure solutions. These advanced bio-adhesives demonstrate high strength, re-adhesion capabilities, and safety, outperforming current surgical glues.

Keywords:
Supramolecular gluebiocompatible adhesivessurgical adhesives

More Related Videos

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles
07:58

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles

Published on: November 14, 2018

8.2K
Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
07:04

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

2.4K

Related Experiment Videos

Last Updated: Jun 25, 2026

Genetic Incorporation of Biosynthesized L-dihydroxyphenylalanine DOPA and Its Application to Protein Conjugation
10:24

Genetic Incorporation of Biosynthesized L-dihydroxyphenylalanine DOPA and Its Application to Protein Conjugation

Published on: August 24, 2018

7.9K
Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles
07:58

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles

Published on: November 14, 2018

8.2K
Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
07:04

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

2.4K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surgical Innovation

Background:

  • Sutures are standard for wound closure but carry risks of invasiveness and contamination.
  • Surgical adhesives offer less invasive alternatives, with supramolecular adhesives presenting novel solutions.
  • Current bio-adhesives have limitations in strength and re-adhesion properties.

Purpose of the Study:

  • To synthesize and characterize novel supramolecular polymers using dopamine as a self-assembling unit.
  • To evaluate the adhesive properties, mechanical strength, and biocompatibility of these new materials.
  • To compare the performance of these novel adhesives against commercially available surgical adhesives.

Main Methods:

  • Synthesis of dopamine-based polymers with varying monomer feed ratios and cross-linking levels.
  • Mechanical testing to determine yield strength and tensile properties.
  • Assessment of re-adhesion capabilities, cytotoxicity (cell viability assays), and performance in aqueous environments.
  • Evaluation of removal using benign organic solvents.

Main Results:

  • The synthesized dopamine-based polymers function as highly effective adhesives.
  • Adhesion strength and material properties are tunable via monomer ratios and cross-linking.
  • These materials exhibit at least two times higher yield strength than BioGlue and Tisseel.
  • Demonstrated significant re-adhesion, non-cytotoxicity (>90% cell viability), and stable performance in aqueous conditions.
  • Successful removal using ethanol was confirmed.

Conclusions:

  • Dopamine-based supramolecular polymers represent a promising new class of bio-adhesives.
  • These materials offer superior mechanical strength and re-adhesion compared to existing options.
  • Their biocompatibility and performance in wet environments suggest significant potential advantages for surgical applications.