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Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons
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Putting the brakes on axonal branching.

Ismael Ferrer1, Chadni Sanyal2, Marie-Jo Moutin2

  • 1Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Trends in Neurosciences
|May 17, 2024
PubMed
Summary

Researchers discovered a new signaling pathway controlling axon branching in mouse neurons. Glycogen synthase kinase 3β (GSK3β) phosphorylation of microtubule-associated protein 1B (MAP1B) limits branching by affecting microtubule tyrosination.

Keywords:
axon branchingcortical developmentmicrotubulestubulin tyrosination

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