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The sphinx helps to answer the riddle of cardiac regeneration
Jae Woo Jung1, Timothy Hla2, Zoltan Arany1
1Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Trends in Endocrinology and Metabolism: TEM
|May 17, 2024
Abstract:
Cardiomyocyte (CM) death drives heart failure worldwide, and efficient CM regeneration remains a fervently pursued but unachieved goal. Ji and colleagues recently described a novel approach to regeneration by orchestrating divergent sphingolipid signaling pathways in CMs and cardiac fibroblasts (CFs). The findings uncover new biology and offer interesting translational opportunities.
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