Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

60
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
60
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

219
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
219
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

445
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
445
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

111
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
111
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

228
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
228

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Importance of Fostering International Collaboration for Optimal Outcomes of Kawasaki Disease Worldwide: A Science Advisory From the American Heart Association.

Journal of the American Heart Association·2026
Same author

MDA5-associated juvenile dermatomyositis and interstitial lung disease from rapidly progressive to silent: a report of three cases in South African children and a review of the literature.

Clinical rheumatology·2026
Same author

Assessing Seroprevalence and Infection Dynamics of Oncogenic Gammaherpesviruses in South African Paediatric Patients Presenting with Inflammatory Conditions.

International journal of molecular sciences·2026
Same author

Influence of sport mouth-formed type mouthguards on saliva secretion and composition during jaw activity: a pilot study.

BMC oral health·2026
Same author

[Outcomes of bimaxillary osteotomy for obstructive sleep apnoea].

Nederlands tijdschrift voor tandheelkunde·2026
Same author

[Obstructive sleep apnoea in children with Down s syndrome: challenges and treatment strategies].

Nederlands tijdschrift voor tandheelkunde·2026

Related Experiment Video

Updated: Jun 26, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.5K

Scurvy masquerading as IgA vasculitis.

Hanna L Kassa1, S Singh2, M Douglas-Jones3

  • 1Department of Pediatric Rheumatology, Red Cross Children's Hospital, University of Cape Town, Cape Town, South Africa. Hanna.lishan@aau.edu.et.

Pediatric Rheumatology Online Journal
|May 17, 2024
PubMed
Summary
This summary is machine-generated.

Scurvy, or vitamin C deficiency, can present with varied symptoms in children, including irritability and pain. Early diagnosis and treatment are crucial for recovery.

Keywords:
Henoch Schonlein PurpuraIgA vasculitisPurpuric-rashScurvySelective-dietVitamin-C

More Related Videos

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
10:24

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

13.7K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

19.9K

Related Experiment Videos

Last Updated: Jun 26, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.5K
Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
10:24

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

13.7K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

19.9K

Area of Science:

  • Pediatrics
  • Nutritional Science
  • Dermatology

Background:

  • Vitamin C deficiency (scurvy) is rare but can affect children with poor diets, malabsorption, or restrictive eating habits.
  • Symptoms include fatigue, irritability, joint pain, edema, gum swelling, bruising, and delayed healing.
  • Early recognition and intervention are vital to prevent severe outcomes.

Observation:

  • A 13-year-old boy with developmental delay presented with symptoms mimicking IgA vasculitis.
  • Clinical signs included irritability, appetite loss, skin lesions, gum swelling, arthritis, edema, weight loss, and anemia.
  • Investigations revealed scurvy, confirmed by surgical, skin biopsy, and X-ray findings.

Findings:

  • Scurvy diagnosis requires considering musculoskeletal, mucocutaneous, and constitutional symptoms.
  • Detailed dietary history is key, focusing on vitamin C intake.
  • Imaging and skin pathology can support diagnosis; rapid response to vitamin C treatment is diagnostic and therapeutic.

Implications:

  • Scurvy should be a differential diagnosis in children with unexplained symptoms.
  • Prompt identification and treatment improve patient outcomes.
  • Raising awareness among healthcare providers is essential for timely diagnosis.