Related Experiment Video
Updated: Sep 3, 2026
13:01
Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 24, 2014
Palindromic rheumatism and Felty's syndrome
Annals of the Rheumatic Diseases
|September 1, 1985
Abstract:
The coexistence of palindromic rheumatism and Felty's syndrome in a single patient is described. It is likely that these two manifestations are linked with the patient's possession of HLA-DR4 and that they are prodromata of the patient's eventual development of rheumatoid arthritis.
Insights
Palindromic rheumatism and Felty's syndrome coexisting in one patient may indicate future rheumatoid arthritis development. This association is likely linked to the patient's HLA-DR4 status.
Area of Science:
- Rheumatology
- Immunogenetics
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease.
- Palindromic rheumatism and Felty's syndrome are distinct clinical manifestations that can occur in RA patients.
Observation:
- A case study detailing the simultaneous occurrence of palindromic rheumatism and Felty's syndrome in a single patient.
- The patient's genetic profile was analyzed for specific human leukocyte antigen (HLA) types.
Findings:
- The patient possessed the HLA-DR4 allele.
- The coexistence of these conditions is hypothesized to be associated with HLA-DR4.
- These symptoms may represent early indicators, or prodromata, of developing rheumatoid arthritis.
Implications:
- This case highlights a potential link between specific autoimmune manifestations and HLA-DR4.
- Understanding these prodromal symptoms could aid in early diagnosis and intervention for rheumatoid arthritis.
- Further research into HLA associations may refine diagnostic criteria for autoimmune rheumatic diseases.
Related Concept Videos
03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
01:23Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
01:26Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
01:27Streptococcal Pharyngitis
Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...