Related Experiment Video
Updated: Jun 15, 2026
08:58
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
15.9K
Hydroxycitrate delays early mortality in mice and promotes muscle regeneration while inducing a rich hepatic
Isabel Espadas1, María Ángeles Cáliz-Molina1, Raúl López-Fernández-Sobrino1
1Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.
Aging Cell
|May 18, 2024
Summary
ATP citrate lyase (ACLY) inhibitors show potential in metabolism and aging. Studies reveal ACLY inhibitors delay mortality, impact lipid accumulation, and influence muscle regeneration and function in aging processes.
Area of Science:
- Biochemistry
- Metabolism
- Aging Research
Background:
- ATP citrate lyase (ACLY) plays a role in metabolism.
- ACLY inhibitors may impact aging and age-related diseases.
Purpose of the Study:
- Investigate the role of ACLY and its inhibitors in aging.
- Examine the physiological consequences of ACLY inhibition.
Main Methods:
- Correlated hepatic phospho-active ACLY with human health metrics.
- Administered ACLY inhibitors (potassium hydroxycitrate, SB-204990, bempedoic acid) to mice and cell cultures.
- Assessed mortality, lipid accumulation, wound healing, and locomotor function.
Main Results:
- Hepatic ACLY correlated with overweight and liver disease scores in humans.
- Potassium hydroxycitrate delayed mortality in mice.
- ACLY inhibitors induced lipid accumulation in hepatocytes and mouse livers.
- Potassium hydroxycitrate modulated wound healing and locomotor function, improving muscle atrophy recovery.
Conclusions:
- ACLY and its inhibitors are implicated in aging processes.
- ACLY inhibition affects metabolism, mortality, and muscle regeneration.
- Further research into ACLY inhibitors for age-related conditions is warranted.
More Related Videos
Related Concept Videos
01:24Liver Regeneration
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
01:24Muscle Recovery and Fatigue
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...