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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Classification of Leukocytes01:30

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Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
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Leukemia Cutis in Relapsed Acute Myeloid Leukemia: A Call for Distinct Classification.

William J Nahm1, Michelle Juarez2, Maher Abdul-Hay3

  • 1New York University Grossman School of Medicine, New York City, NY, USA.

The American Journal of Case Reports
|May 18, 2024
PubMed
Summary

Leukemia cutis, skin infiltration by malignant myeloid cells, is rarely reported in relapsed acute myeloid leukemia. This case suggests patients with relapsed acute myeloid leukemia and leukemia cutis may have poorer outcomes, needing distinct classification and research.

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Area of Science:

  • Hematology
  • Dermatology
  • Oncology

Background:

  • Acute myeloid leukemia (AML) involves myeloid precursor proliferation and maturation arrest.
  • Leukemia cutis is skin infiltration by malignant myeloid cells, with unclear pathogenesis.
  • Limited reports exist for leukemia cutis in relapsed AML.

Observation:

  • A 59-year-old woman with relapsed AML presented with anemia, thrombocytopenia, and skin nodules.
  • Leukemia cutis was diagnosed in the context of relapsed AML.
  • Salvage chemotherapy failed, and the patient died within a month.

Findings:

  • This case highlights the underreporting of leukemia cutis in relapsed AML.
  • Patients with relapsed AML and leukemia cutis may experience worse clinical outcomes.
  • A distinction between primary and relapsed AML with leukemia cutis is warranted.

Implications:

  • Relapsed AML with leukemia cutis should be a distinct classification for targeted research.
  • Further research into aggressive therapeutic targets and survival rates is needed.
  • Increased vigilance and lower biopsy thresholds for cutaneous lesions in treated hematologic malignancies are recommended.