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Dynamic Mechanism of Cerebral Venous Disruption: Longitudinal Evidence From a Community-Based Cohort
Zi-Yue Liu1, Pei Wang1, Fei-Fei Zhai1
1Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Journal of the American Heart Association
|May 18, 2024
Summary
Fewer deep medullary veins (DMVs) correlate with faster white matter damage and varied brain volume changes. This study reveals dynamic patterns of brain injury linked to DMVs damage.
Area of Science:
- Neuroimaging
- Brain structure analysis
- White matter integrity
Background:
- Deep medullary veins (DMVs) play a crucial role in brain function.
- Understanding structural brain injury related to DMVs damage is essential.
Purpose of the Study:
- To investigate the temporal and spatial patterns of structural brain injury associated with deep medullary veins (DMVs) damage.
- To explore the relationship between DMVs number and brain structural measurements over time.
Main Methods:
- Longitudinal analysis of the population-based Shunyi cohort study.
- Susceptibility-weighted imaging for DMVs identification.
- Vertex-wise cortex and diffusion map analysis using FSL and FreeSurfer.
Main Results:
- A lower number of DMVs was linked to faster white matter microstructural integrity disruption (increased mean and radial diffusivity).
- A bidirectional association was observed between DMVs number and changes in brain volumes.
- Mild DMVs disruption correlated with cortical enlargement, while severe disruption showed significant brain atrophy, particularly in frontal and parietal lobes.
Conclusions:
- Findings elucidate the dynamic patterns of brain parenchymal lesions resulting from DMVs injury.
- The study highlights the complex interactions and chronological roles of pathological mechanisms involved in DMVs-related brain damage.
Keywords:
brain atrophydeep medullary veinslongitudinal studyneurodegenerative diseasewhite matter microstructureMore Related Videos
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