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Related Concept Videos

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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Construction Of A Nomogram Based On Clinicopathologic Features To Predict The Likelihood Of No. 253 Lymph Node Metastasis In Rectal Cancer Patients.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Construction Of A Nomogram Based On Clinicopathologic Features To Predict The Likelihood Of No. 253 Lymph Node Metastasis In Rectal Cancer Patients.

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Construction of a nomogram based on clinicopathologic features to predict the likelihood of No. 253 lymph node metastasis in rectal cancer patients.

Weixiang Chen1,2, Zhiming Cai1,2, Jinfeng Zhou1,2

  • 1The School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, 350122, China.

Langenbeck'S Archives of Surgery
|May 18, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

High-risk factors for rectal cancer No.253 lymph node metastasis (LNM) include CT-detected lymphadenectasis, T4-stage, undifferentiation, and elevated Ca199. A predictive nomogram aids surgeons in clinical decision-making for rectal cancer LNM.

Keywords:
Inferior mesenteric arteryNo.253 lymph node metastasisNomogramPreoperative factors

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiology

Background:

  • Rectal cancer lymph node metastasis (LNM) significantly impacts prognosis.
  • Accurate prediction of No.253 LNM is crucial for treatment planning.

Purpose of the Study:

  • To identify independent risk factors for No.253 LNM in rectal cancer patients.
  • To develop and validate a predictive nomogram for individualized risk assessment of No.253 LNM.

Main Methods:

  • Retrospective analysis of 425 rectal cancer patients undergoing laparoscopic surgery.
  • Multivariate logistic regression to identify independent risk factors.
  • Construction and validation of a risk prediction nomogram using discrimination, calibration, and clinical benefit analyses.
Rectal cancer

Main Results:

  • Independent risk factors for No.253 LNM identified: No.253 lymphadenectasis on CT (OR 10.697), preoperative T4-stage (OR 4.431), undifferentiation (OR 3.753), and elevated preoperative Ca199 (>27 U/ml) (OR 2.628).
  • The constructed nomogram demonstrated high discriminative ability (AUC 0.865) and good calibration.
  • Decision curve analysis indicated clinical utility for threshold probabilities between 1% and 50%.

Conclusions:

  • Preoperative CT-detected No.253 lymphadenectasis, T4-stage, tumor undifferentiation, and elevated Ca199 are significant independent risk factors for No.253 LNM.
  • The developed nomogram provides a valuable tool for surgeons to make informed clinical decisions regarding rectal cancer management.