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Related Experiment Video

Updated: Jun 26, 2025

Determining heat and mechanical pain threshold in inflamed skin of human subjects
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Differences in the epidermal pain threshold between different needle puncture sites.

Katsuhide Masui1, Takashi Asai2

  • 1Department of Anesthesiology, Dokkyo Medical University Saitama Medical Center, 2-1- 50 Minami-Koshigaya, Koshigaya, Saitama, 3438555, Japan. k-masui@dokkyomed.ac.jp.

Journal of Anesthesia
|May 18, 2024
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Summary

Needle punctures can cause varying levels of pain depending on the body site. This study quantifies pain thresholds at 13 skin sites, finding lower thresholds at the wrists, suggesting a need for analgesia in these areas.

Keywords:
Epidermal pain thresholdNeedle puncturePeripheral nerve block

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Area of Science:

  • Pain research
  • Dermatology
  • Anesthesiology

Background:

  • Needle punctures for medical procedures like nerve blocks or catheter placements can cause significant patient pain.
  • Current understanding of pain variability across different skin puncture sites is limited.

Purpose of the Study:

  • To quantify and compare pain thresholds at 13 distinct skin puncture sites.
  • To identify body locations with significantly different pain sensitivities to needle insertion.

Main Methods:

  • A study involving 30 volunteers was conducted after ethical approval and informed consent.
  • An algometer was used to measure pain thresholds at 13 different body sites.

Main Results:

  • Pain thresholds varied significantly across the 13 tested skin sites compared to the cubital fossa control.
  • Lower pain thresholds were observed at the lateral and medial carpus (wrists).
  • Higher pain thresholds were recorded at the olecranon, forehead, and shoulders.

Conclusions:

  • Significant differences in pain perception exist among various needle puncture sites.
  • Analgesic interventions may be necessary for procedures involving low-pain-threshold sites, such as the wrists.