Related Experiment Video
Updated: Jun 26, 2025
10:49
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
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Anti-Angiogenic Tyrosine Kinase Inhibitor-Related Toxicities Among Cancer Patients: A Systematic Review and
Tai Van Nguyen1,2,3,4, Diaddin Hamdan1,4,5, Géraldine Falgarone1,4,6
1Université Paris Cité, INSERM UMR_S942, MASCOT, 75006, Paris, France.
Targeted Oncology
|May 18, 2024
Summary
This meta-analysis reveals that anti-angiogenic tyrosine kinase inhibitors (TKIs) have a 56.1% prevalence of severe toxicities in cancer patients. Toxicity varies by TKI, cancer type, and patient factors, informing personalized treatment choices.
Area of Science:
- Oncology
- Pharmacology
- Clinical Trials
Background:
- Targeting angiogenesis is crucial for advanced cancer therapy.
- Anti-angiogenic tyrosine kinase inhibitors (TKIs) are widely used but have unresolved toxicity concerns.
Conclusions:
- Anti-angiogenic TKI monotherapies exhibit significant toxicity profiles.
- Findings support personalized TKI selection based on patient age, ethnicity, comorbidities, and comedications.
- Recommendations for optimized treatment strategies are enabled by understanding TKI-specific toxicities.
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