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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Updated: Jun 26, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Network-based approach for drug repurposing against mpox.

Kang Tang1, Qianru Sun2, Jinfeng Zeng3

  • 1School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou 510275, PR China; School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, PR China; School of Public Health, Guangdong Medical University, Dongguan 523808, PR China.

International Journal of Biological Macromolecules
|May 18, 2024
PubMed
Summary
This summary is machine-generated.

Researchers identified potential mpox virus (MPXV) treatments by analyzing poxvirus-human interactions. Network medicine identified 23 promising repurposed drugs with minimal side effects for MPXV infection.

Keywords:
ComorbidityDrug repurposingMpoxVirushost interaction

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Area of Science:

  • Virology
  • Network Medicine
  • Pharmacology

Background:

  • The mpox virus (MPXV) outbreak poses a global health risk.
  • There is an urgent need for effective mpox treatments due to a lack of specific antiviral drugs.

Purpose of the Study:

  • To identify potential drug candidates for mpox treatment using a network medicine approach.
  • To investigate poxvirus-host interactions and discover novel therapeutic strategies.

Main Methods:

  • Utilized a network medicine framework to analyze poxvirus-human protein-protein interaction networks.
  • Applied network proximity and drug-target interaction predictions to identify candidate drugs.
  • Analyzed comorbidity data to understand mpox pathogenesis and disease associations.

Main Results:

  • Poxviruses were found to target key hub proteins in the human interactome, which tend to cluster within specific modules.
  • Mpox showed a strong association with immune system diseases through comorbidity analysis.
  • Identified 268 potential drugs, with 23 selected as top candidates based on minimal side effects and proximity to MPXV targets.

Conclusions:

  • Network medicine provides a powerful framework for understanding MPXV pathogenesis.
  • Repurposing existing drugs offers a viable strategy for rapid development of mpox treatments.
  • The identified drug candidates warrant further investigation for clinical efficacy against mpox.