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Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
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A high-throughput response to the SARS-CoV-2 pandemic.
Lynn Rasmussen1, Shalisa Sanders1, Melinda Sosa1
1Southern Research, Birmingham, AL, USA.
SLAS Discovery : Advancing Life Sciences R & D
|May 18, 2024
Summary
High-throughput screening in a biosafety level 3 (BSL-3) environment accelerated COVID-19 research. Southern Research Institute
Area of Science:
- Virology
- Drug Discovery
- Public Health
Background:
- The COVID-19 pandemic necessitated rapid scientific advancement.
- Decades of prior research provided a foundation for swift responses.
- Multiple sectors collaborated to develop treatments.
Purpose of the Study:
- To summarize the role of high-throughput screening in pandemic response.
- To detail contributions made in a biosafety level 3 (BSL-3) setting.
- To outline challenges faced during rapid research and development.
Main Methods:
- Development of high-throughput screening assays.
- Application of these methods within a BSL-3 laboratory.
- Adaptation to evolving viral characteristics and pandemic pressures.
Main Results:
- Accelerated identification and development of potential clinical treatments.
- Demonstrated the efficacy of advanced screening in a BSL-3 environment.
- Provided insights into managing research under pandemic conditions.
Conclusions:
- High-throughput screening in BSL-3 settings is crucial for pandemic preparedness.
- Federal funding for basic and applied research is vital.
- Collaboration across institutions enhances response capabilities.
