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Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The Central Dogma01:20

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The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Bioluminescent Bacterial Imaging In Vivo
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Bacteria-based cancer therapy: Looking forward.

My-Van Tieu1, Duc-Trung Pham1, Sungbo Cho2

  • 1Department of Electronic Engineering, Gachon University, Seongnam-si 13120, Republic of Korea.

Biochimica Et Biophysica Acta. Reviews on Cancer
|May 18, 2024
PubMed
Summary

Bacteria-based cancer therapy leverages tumor-colonizing bacteria for treatment. This review covers its history, interdisciplinary progress, clinical challenges, and recent advancements in developing novel cancer therapeutics.

Keywords:
Bacteria cancer therapyBiological engineeringEngineered bacteriaWild-typed bacteria

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Area of Science:

  • Oncology
  • Microbiology
  • Biotechnology

Background:

  • Bacteria-based cancer therapy utilizes the prevalence of bacteria within tumors as a therapeutic strategy.
  • The field has experienced significant growth, highlighting bacteria's role in controlling cancer targets.

Purpose of the Study:

  • To review the global cancer landscape and the historical timeline of bacteria in cancer therapy.
  • To explore the impact of interdisciplinary collaboration on the evolution of these therapies.
  • To identify challenges for clinical trial acceptance and discuss recent advancements.

Main Methods:

  • Comprehensive literature review of bacteria-based cancer therapy.
  • Analysis of historical data and interdisciplinary contributions.
  • Evaluation of current challenges and technological progress.

Main Results:

  • Discussion of the global cancer situation and the timeline of bacterial therapy integration.
  • Identification of key interdisciplinary collaborations driving therapeutic evolution.
  • Outline of hurdles for clinical adoption and summary of cutting-edge developments.

Conclusions:

  • Bacteria-based cancer therapy presents innovative strategies for diverse cancer treatments.
  • Overcoming clinical challenges is crucial for broader acceptance and application.
  • Technological advancements continue to expand the potential of this therapeutic approach.