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Lactate-induced lactylation and cardiometabolic diseases: From epigenetic regulation to therapeutics

Jie Lin1, Jun Ren1

  • 1Department of Cardiology, Zhongshan Hospital Fudan University, Shanghai, 200032, China; Shanhai Institude of Cardiovascular Diseases, Shanghai, 200032, China; National Clinical Research Center for Interventional Medicine, Shanghai, 200032, China.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|May 18, 2024
PubMed

Insights

Histone lactylation, a novel epigenetic modification, is linked to cardiometabolic diseases (CMDs) like obesity and diabetes. Understanding lactylation

Area of Science:

  • Biochemistry
  • Epigenetics
  • Cardiovascular Science

Background:

  • Cardiometabolic diseases (CMDs) are chronic conditions stemming from metabolic issues like obesity, type 2 diabetes, and hypertension.
  • Emerging research links histone lactylation, a post-translational modification, to CMD development via epigenetic pathways.

Purpose of the Study:

  • To explore the role of histone lactylation in the pathogenesis of cardiometabolic diseases.
  • To elucidate the molecular, cellular, and physiological mechanisms underlying lactylation's impact on CMDs.

Main Methods:

  • Review of recent scientific literature on histone lactylation and cardiometabolic diseases.
  • Analysis of epigenetic mechanisms involved in lactylation.
  • Investigation of cellular and tissue-specific effects of lactylation.

Main Results:

  • Histone lactylation is associated with the pathogenesis of cardiometabolic diseases.
  • Lactylation influences key metabolic, inflammatory, and cardiovascular functions.
  • The effects of lactylation are specific to cell type and tissue.

Conclusions:

  • Further understanding of lactylation in CMDs offers new insights into disease development.
  • Investigating lactylation may lead to novel strategies for controlling risk factors.
  • Targeting lactylation could pave the way for new therapeutic approaches for CMDs.

Keywords:
CardiovascularLactylationMetabolic diseasesPost-translational modifications

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