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Inadequate linear catch-up growth in children born small for gestational age: Influencing factors and underlying

Anran Tian1, Fucheng Meng1, Sujuan Li1

  • 1Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Reviews in Endocrine & Metabolic Disorders
|May 19, 2024
PubMed

Insights

Some children born small for gestational age (SGA) don't experience catch-up growth, remaining short. This review examines growth hormone-insulin-like growth factor axis and growth plate factors in SGA children with growth failure.

Area of Science:

  • Pediatric endocrinology
  • Growth and development research

Background:

  • A subset of children born small for gestational age (SGA) exhibit persistent short stature due to failed catch-up growth.
  • The precise mechanisms underlying catch-up growth failure in SGA children remain incompletely understood.

Purpose of the Study:

  • To review current research on the growth hormone-insulin-like growth factor (GH-IGF) axis and growth plate in SGA children lacking catch-up growth.
  • To explore factors influencing catch-up growth and potential molecular mechanisms in SGA populations.
  • To assess the potential of nutritional interventions, dietary patterns, probiotics, and pharmacotherapy in promoting catch-up growth.

Main Methods:

  • Literature review of existing research.
  • Analysis of studies focusing on the GH-IGF axis and growth plate development.
  • Exploration of factors affecting catch-up growth and molecular pathways.

Main Results:

  • The review synthesizes current knowledge on the GH-IGF axis and growth plate function in SGA children with growth failure.
  • Identified factors influencing catch-up growth and potential molecular targets are discussed.
  • The potential efficacy of interventions like nutritional support and drug therapy is considered.

Conclusions:

  • Understanding the mechanisms of catch-up growth failure in SGA children is crucial for developing effective interventions.
  • Further research into the GH-IGF axis, growth plate, and molecular factors is warranted.
  • Investigating interventions such as nutrition, probiotics, and medication may offer therapeutic strategies for improving growth outcomes in SGA children.

Keywords:
Catch-up growthGrowth hormone-insulin-like growth factor axisGrowth plateShort statureSmall for gestational age

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