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Updated: Jun 26, 2025

Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Widespread form of Majocchi's granuloma in a kidney transplant recipient
Cihan Uysal1, Hanife Oguz2, Hasan Cifci2
1Department of Nephrology, Erciyes University Medical Faculty, Köşk Distinct, Dede Efendi Street, 38039, Melikgazi, Kayseri, Turkey. drcihanuysal@hotmail.com.
Abstract:
Kidney transplantation is the encouraged kidney replacement therapy due to providing more prolonged survival with a better quality of life. Unfortunately, kidney transplant recipients are susceptible to infections because of long-term utilization of immunosuppression. Despite dermatophyte infections are generally not life-threatening, the clinical significance has been recently enhanced by an increasing number of immunocompromised patients. We have presented a rare dermatophytosis course, Majocchi's granuloma, that spreads to all extremities during the early post-transplant period. A young kidney transplant recipient was exposed to intensive immunosuppression therapy due to acute rejection in the early period of post-transplantation. After four months, numerous nodular skin lesions were raised on various body parts. An invasive fungal infection was identified in the skin biopsy. Also, Trichophyton rubrum was isolated in the tissue cultures. Consequently, the patient was diagnosed with Majocchi's granuloma. An effectual treatment was attained with an oral terbinafine tablet. Majocchi's granuloma is a distinct form of dermatophytosis characterized by the spreading of infection into the dermis. In this unexpected case, we alerted physicians to opportunistic infections in the kidney transplant recipient.
Insights
Kidney transplant recipients on immunosuppression can develop rare skin infections like Majocchi's granuloma. Early diagnosis and oral terbinafine treatment were effective in this case of invasive fungal infection.
Area of Science:
- Nephrology
- Dermatology
- Infectious Diseases
Background:
- Kidney transplantation offers improved survival and quality of life but necessitates long-term immunosuppression.
- Immunosuppression increases kidney transplant recipients' susceptibility to opportunistic infections.
- Dermatophyte infections, though typically benign, pose risks to immunocompromised individuals.
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