Related Experiment Video

Updated: Aug 15, 2026

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
11:13

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

Kinetics of mammary and intestinal IgA-producing cells in the lactating rat

M J Parmely

    Journal of Reproductive Immunology
    |August 1, 1985
    PubMed

    IgA-producing B lymphocytes in the lactating mouse mammary gland are thought to be derived from lymphoid tissues associated with the small intestine. By contrast, adoptive transfer studies in the rat have failed to confirm a simple entero-mammary migration of IgA plasma cell precursors during lactation. To explain this discrepancy we postulated that recent cIgA+ cell immigrants undergo extensive local proliferation in the rat mammary gland. The present study tested this hypothesis by determining mitotic indices of cIgA+ cells in the gland during lactation. The results did not support this contention and suggest that rat mammary cIgA+ B cells are not derived from the same pool of precursors providing IgA-producing B cells for the small intestine.

    More Related Videos

    Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs06:25

    Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs

    Published on: March 5, 2016

    Intravital Subcellular Microscopy of the Mammary Gland04:14

    Intravital Subcellular Microscopy of the Mammary Gland

    Published on: June 24, 2022

    Related Concept Videos

    Transcytosis of IgG01:15

    Transcytosis of IgG

    Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
    IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
    Renewal of Intestinal Stem Cells01:23

    Renewal of Intestinal Stem Cells

    The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...